Pyrexia of Unknown Origin (PUO)

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21 Jul 2016 - General

Pyrexia is defined as body temperature of 37.8 to 38 celcius or higher. Pyrexia can be due to any kind of infection (viral or bacterial), or non-infective causes like trauma, surgery, adverse reaction a drug, antibiotic associated fever, neoplastic disease and autoimmune disease. Pyrexia of unknown origin (PUO) is the condition refers to patients with persistent or frequently recuuring fever for  3 weeks and no specific obvious causes of the fever has been found after 1 or more medical examnitaion, assessment and investigation. Patient with pyrexia of unknown origin will require a thorough investigations to find out what is the cause of it. What are the important infective causes of pyrexia of unknow origin ????

The main important infective causes of pyrexia of unknown origin are abscess, infective endocarditis, tuberculosis and zoonotic infection. Intra-abdominal abscess can be associated with intermittent spike of temperature. Imaging like CT-scan is required in diagnosis intra-abdominal abscess, and the crucial management is the drainage of abscess (if big area of abscess or if clinically indicated) and antibiotic. Infective endocarditis is another important cause of PUO. On examination, it may...
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