Helicobacter Pylori

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22 Jul 2016 - General

Helicobacter Pylori is a gram-negative spiral bacillus, that can cause inflmmation and ulceration of the mucosa lining in the stomach and duodenum. It was identified by the 2 scientists - Barry Marshall and Robin Warren in Australia. Its transmission route is likely from oral secretion, or faecal-oral spread or both. Most of people infected with Helicobacter Pylori will be asymptomatic. Some infected cohort (around 10% to 20%), will be symptomatic with epigastric pain, bloating, nausea, belching, vomiting, or malaena. H.Pylori can cause petic ulcer diasea, and will increase the risk of stomach cancer. There are a few diagnostic option for H.Pylori infection, like urea breath test, OGD and clo-test +/-  biopsy for histology, stool antigen for H.Pylori. What are the management option for H.Pylori infection???

Treatment regimens for H. pylori – The regimen most commonly recommended for first-line treatment of H. pylori is triple therapy with a PPI (lansoprazole 30 mg twice daily, omeprazole 20 mg twice daily, pantoprazole 40 mg twice daily, rabeprazole 20 mg twice daily, or esomeprazole 40mg once daily), amoxicillin (1 g twice daily), and clarithromycin (500 mg twice daily) for 7 to 14
days. Metronidazole (500 mg twice daily) can be substituted for amoxicillin, but only in penicillin-
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