“Liver on a chip” closely mimics hepatocyte metabolism

“Liver on a chip” closely mimics hepatocyte metabolism

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Technology that can accurately demonstrate liver metabolism, and which may be used as a tool to determine toxicity and metabolism of drug candidates may soon be developed.
26 Jul 2016 - General
Investigators have been developing in-vitro liver models for 40 years, but all of those systems ignore the distinct patterns of metabolically active hepatocytes that exist within the liver sinusoid" says Martin Yarmush, MD, PhD, director of the MGH-CEM and the paper's senior author. "We hope this tool, which displays zonation of carbohydrate and nitrogen metabolism, in addition to drug detoxification and alcohol degradation, will improve our ability to understand and predict the ef...
 (Total 81 words)