The importance of "Blinding" in Randomized Control Trial

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3 Sep 2016 - General

The "blinding" process in a research study means that the study participants, staff who have contact with them, persons making measurements, and those who ascertain and adjudicate the outcome do not know the study group assignments. (of intervention vs placebo, or treatment A vs treatment B). The use of "blinding" can prevent bias caused by co-interventions - medications, therapies, or behaviours other than the study intervention that change the risk of developing the outcome of interests. "Blinding" can also minimize biased ascertainment and adjudication of outcomes. In the randomized control trial, "Blinding" the intervention ia as important as randomization process, and serves to control co-interventions and biased outcome ascertainment and adjudication.

Yes Mark Edmon Tan , if there is no “Blinding” in the randomized controlled trial, the investigator may be tempted to look more carefully for the outcomes in the untreated group or to diagnose the outcome more frequently. For example, in an unblended trial of drug A Vs. placebo (with known side effect of causing headache), then the investigator may be more likely to ask the participants in the treatment group wit...
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Blinding is important because observer bias might affect the outcome of the result, especially in randomized controlled trial studies. This is a huge question mark for this type of study if there is no blinding involved. Observers have to get crafty with being able to "blind" the intervention. I have seen one study wherein impact of rice and corn as source of energy for training was compared. The observer was able to transform the corn kernel similarly to a grain of rice. Speaking of b...
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