Ulcerative Colitis - Managment Plan

Created by:

3 Sep 2016 - General

There are a few medications that are available to treat ulcerative colitis, like steroid (intravenous hydrocortisone or oral prednisiolone), 5-aminosalicylic acid (5-ASA)/mesalazine, azathioprinne, biologic agent (Infliximab, adalimumab, golimumab), and bio-simillar product. In an acute flare of colitis or 1st presentation of acute colitis, intravenous steroid is required to induce remission of the disease activity, and patient can be started with mesalazine to maintain the remission of disease activity. Azathioprine is the next step if patient has reccurrent flare with mesalazine or no effect from mesalazine. The next step will be biologic agent. Rescue therapy with Infliximab can be used as well for patient with acute flare of colitis that was not responed to intravenous steroid. Some specialist do use cyclosporin as well.

Yes, Rajinda Asalage 5-ASA / Mesalazine is very useful in maintaining patient with ulcerative colitis in clinical remission. But, it is not as useful in the case of acute flare of colitis. Usually intravenous hydrocortisone is the drug of choice to treat patient with acute flare of colitis, followed by switching to oral prednisolone, with tapering dose (if patient was improving on intravenous hydrocortisone). If ...
 (Total 116 words)
A patient with mild symptoms can be manage symptomatically. For loose stools, anti-diarrheals. Dietary habits can be modified to reduce loose stools. Aminosalicylates can be used to relieve the inflammation inside the intestine and steroid drugs also can be used. It may take few weeks to resolve the inflammation. A patient with mild to moderate symptoms can be treated with cyclosporine drugs and biologics can be used too. If the condition does not get better, it is better to go into the surgical...
 (Total 102 words)