5-aminosalicylic acid (5-ASA)Created by:
5-aminosalicy acid (5-ASA) is a common medical treatment for mild-to-moderate ulcerative coitis. The first 5-ASA product is sulfasalazine. Sulfasalazine is linked to sulfapyridine by a diazo bond that is cleaved by colonic bacteria, and the active ingredient is 5-ASA. There are a few side effects from sulfasalazine like infertility due to changes in sperm count and morphology, agranulocytosis, autoimmune hemolytic anaemia, folic acid deficiency, nausea, vomiting, fever and rash. The newer preparation only contain 5-ASA, that are carried through and released in the small bowel. 5-ASA is avaliable in a oral formulation forms for oral intake, and it is also available in enema form to be used per rectum (which can act locally on the colonic mucosa).