Ulcerative colitis and PregnancyCreated by:
There are 2 important factors of having ulcerative colitis and being pregnant, which are the effect of the disease itself and also the effect of medications for ulcerative colitis. If the disease activity is well controlled or in clinical remisison, it should not have any negative effect on fertility or pregnancy. If patient has a flare of colitis or having active disease during pregnancy, the risk of fetal loss will be increased. Hence, it is very important to maiantain good control of disease activity before, and during the period of pregnancy. Mesalazine (5-ASA) has a long record of safety in pregnancy, and it should be continue throughout the pregnancy. Sulfasalazine may cause reversible oligospermia, and it should be replaced with new 5-ASA agents, if the male partner (with ulcerative colitis) is planning to start a family. How about other medications for inflammatory bowel disease, like azathioprine, steroid, and anti- tumor necrosis factor agents ??