Weakness of Case-Control studyCreated by:
Case-control design has its own disadvantages as well. Firstly, only one outcome can be studied (like presence or absence of a certain disease). (in cohort or cross-sectional study, we can study several outcome variables.) Secondly, the information available in case-control study is limited, and there is no direct way to estimate the incidence or prevalence of the disease, nor the attributable or excess risk. Case-control study is also susceptible to bias, mainly from two sources, which are the seperate sampling of the case and control, and the retrospective measurement of the predictor variables. Howerver, there are some strategies available to deal with the potential bias in case-control study.