General

The Controversial Effects of SSRIs

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7 Sep 2016 - General
 

 SSRIs ( Selective Serotonin Reuptake Inhibitors ) have been believed for long time to play an extremely important rule as antidepressants and anxiolytics. SSRIs work by preventing the reuptake of the neurotransmitter serotonin. This makes more serotonin available for use in your brain, which was thought to improve the mood.

 Most people have heard of the "chemical imbalance" theory, which states that depression and anxiety disorders are due to disturbed levels of neurotransmitters in the brain such as, in many cases, low serotonin levels. Most believe this theory to be true. But the theory was just that a theory. It sounds scientific, but there was actually no hard evidence behind it.  

 

 Surprisingly, More than 25 million Americans report suffering from social anxiety disorder, which makes them feel embarrassed or severely uncomfortable in public situations. Moreover, SSRIs have been found to increase the fragility of bones causing more fractures among the patients depending on SSRIs for long time

 Studies in the past have showed that increased nerve activity in the amygdala is part of the underlying mechanism that results in anxiety. Basically, those with social phobia have an hyperactive fear center. These new findings provide additional information, suggesting increased serotonin production in the brain may be part of this mechanism.

 Either way, when it comes to treating this anxiety disorder, increasing serotonin in your brain with an SSRI will not soothe your anxiety. It will increase it, making SSRIs a questionable treatment option.

Sources:

https://www.sciencedaily.com/releases/2016/08/160824135045.htm
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4166.html
 

 

Selective serotonin re uptake inhibitors (SSRIs) are used widely as antidepressants. It increases the extracellular level of the neurotransmitter serotonin. These drugs are used in depression, anxiety disorders, obsessive compulsive disorder, stroke recoveries, premature ejaculation and in eating disorders. Depression and manic episode are the two extremities and the people with a normal mental state examination are in the midway between these two conditions. In overdosing, even a normal person ...
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In My opinion, depression and anxiety are two extremes of the spectrum of mood. NOrmal people, or the ones we consider as normal have their mood balanced in the middle. Depending on the situation, it can slide to either side, making you nervous or feel down. In pathological anxiety or depression the patient's mood goes to one of the extreme ends and without help it is difficult for them to find a balance in their mood. That's where drugs come in. What drugs do is pull the mood to the opp...
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