Primary Biliary Cirrhosis (PBC)Created by:
Primary biliary cirrhosis (PBC) mainly affect women in their sixth decade of life. It is the autoimmue disorder of liver, with unkown underlying specific cause of it. The serum autoantibodies related to primary biliary cirrhoiss are serum anti mitocrondrial antibody (anti AMA), anti AMA-M2. Serum IgM level will be elevated in around 90% of patients with primary biliary cirrhoiss. The are a few diseases that can be associated with primary biliary cirrhosis, like sjogren syndrome, autoimmune thyroiditis, scleroderma/CREST, rheumatoid arthritis, dermatomyositis, mixed connective tissue disease, systemic lupus erythematosus, renal tubular acidosis, and idiopathic fibrosis. Sometime, liver biopsy may be needed in the diagnosis of this condition.