Why don't antidepressants work in some patients? Mouse study shows it may be down to your environment

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27 Sep 2016 - General

Tracing the inflammatory markers in an animal model, a new research has found that the environment determines the response to antidepressants.SSRI antidepressants (Selective Serotonin Reuptake Inhibitors, the best known being Prozactm) are amongst the most commonly taken medicines. However, there seems to be no way of knowing in advance whether or not SSRIs will work effectively. Now a group of European researchers has developed a new theory of SSRI action, and tested it in stressed mice. The results, which are presented at the ECNP conference in Vienna, show why the circumstances we find ourselves in may influence whether an antidepressant works or not.

"For an SSRI to work well, you may need to be in a favourable environment. This may mean that we have to consider how we can adapt our circumstances, and that antidepressant treatment would only be one tool to use against depression." 


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Depression is among the most prominent mental health conditions globally, with an estimated 350 million affected worldwide. Although treatment for the condition can vary, the most common treatment, particularly in industrialized countries, is the prescription of antidepressant drugs. However, we should keep in mind that depression is a multifactorial disease. There are the chemical components which are targeted through the pharmacotherapy. The other and even more component is the environmental e...
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