Suicide prevention drug steps closer with Enzyme discoveryCreated by:
We are missing 1 million people World wide commiting suicides.
New study paves the way for a drug to avert suicidal behavior, after identifying an enzyme related to brain inflammation that has the potential to predict and prevent suicide.
ACMSD could be a promising drug target for suicide prevention.
Piclonic acids and quinolinic acids found In high levels.
Patients with suicidal behavior experience persistent inflammation in their blood and cerebrospinal fluid.
Since previous research had shown that both picolinic and quinolinic acid are regulated by the enzyme ACMSD - known to regulate brain inflammation - the researchers conducted a genetic analysis of individuals with suicidal behavior, as well as healthy controls.
From this, they found that individuals who had attempted suicide were more likely to possess a specific variant of ACMSD, and this variant was associated with increased levels of quinolinic acid.
We also want to develop drugs that might activate the enzyme ACMSD and thus restore balance between quinolinic and picolinic acid."
Additionally, since the results show that abnormal levels of picolinic and quinolinic acid can be identified in the blood, the team says they may bring us closer to a blood test that can identify patients at high risk of suicidal behavior.