General

Suicide prevention drug steps closer with Enzyme discovery

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5 Oct 2016 - General
 

We are missing 1 million people World wide commiting suicides.

New study paves the way for a drug to avert suicidal behavior, after identifying an enzyme related to brain inflammation that has the potential to predict and prevent suicide.

ACMSD could be a promising drug target for suicide prevention.

Piclonic acids and quinolinic acids found In high levels.

Patients with suicidal behavior experience persistent inflammation in their blood and cerebrospinal fluid.

Since previous research had shown that both picolinic and quinolinic acid are regulated by the enzyme ACMSD - known to regulate brain inflammation - the researchers conducted a genetic analysis of individuals with suicidal behavior, as well as healthy controls.

From this, they found that individuals who had attempted suicide were more likely to possess a specific variant of ACMSD, and this variant was associated with increased levels of quinolinic acid.

We also want to develop drugs that might activate the enzyme ACMSD and thus restore balance between quinolinic and picolinic acid."

Additionally, since the results show that abnormal levels of picolinic and quinolinic acid can be identified in the blood, the team says they may bring us closer to a blood test that can identify patients at high risk of suicidal behavior.

Mahmoud AbdelAziz
Its not myth, though Its a myth the levels of toxins raised In blood are math. The inflmatory toxins are prevalent in blood with suiciders. Enzyme responsible for the chemical mediators had found by researchers. New drugs will come into picture to control the Enzyme. Definitely It Is helpful In the treatment or adjuant treatment of suicidal tendency.
Yeah, genes may trigger the Enzyme to...
 (Total 124 words)
Mahmoud AbdelAziz
Its not myth, though Its a myth the levels of toxins raised In blood are math. The inflmatory toxins are prevalent in blood with suiciders. Enzyme responsible for the chemical mediators had found by researchers. New drugs will come into picture to control the Enzyme. Definitely It Is helpful In the treatment or adjuant treatment of suicidal tendency.
Yeah, genes may trigger the Enzyme to...
 (Total 124 words)
The study published on Nature has tested the hypothesis that deficient ACMSD activity underlies suicidal behaviour. A suicide attempt was defined as ‘situations in which a person has performed an actually or seemingly life-threatening behavior with the intent of jeopardizing his/her life’. It is good for sure to witness a drug that can break the cycle of suicidal thoughts despite the complicated nature of our brains. However, I believe that people attempting to take their own lives have many oth...
 (Total 114 words)