Conservative vs Conventional Oxygen Therapy on Mortality in an ICU

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6 Oct 2016 - General

Potential harm to the ICU patients reported with Oxygen, that creating hyperoxymic state and A strategy of controlled arterial oxygenation is thus rational but has not been validated in clinical practice.

Researchers of  Italy conducted a clinical trial for 2 years on 480 adult ICU patients who are going to admit in to hospital for 72 hr more.

Patients were randomly assigned to receive oxygen therapy to maintain Pao2 between 70 and 100 mm Hg or arterial oxyhemoglobin saturation (Spo2) between 94% and 98% (conservative group) or, according to standard ICU practice, to allow Pao2 values up to 150 mm Hg or Spo2 values between 97% and 100% (conventional control group).

The primary outcome was ICU mortality. Secondary outcomes included occurrence of new organ failure and infection 48 hours or more after ICU admission.

Among critically ill patients with an ICU length of stay of 72 hours or longer, a conservative protocol for oxygen therapy vs conventional therapy resulted in lower ICU mortality.


Please share your comments and experiences in ICU oxygen therapy.