Management/Treatment Algorithm for Clostridium Difficile infective diarrhoeaCreated by:
Clostridium Difficile infective diarrhoea is an important hospital acquired infection that can lead to significant morbidity and mortality. The general approach in managing patient with clostridium difficile diarrhoea are immediate stopping of unnecesary antibiotic that can potentially lead to it, ensure adequate fluid and electrolytes replacement, patient isolation with proper prevention of spreading and infection control, review proton pump inhibitor use, review other risk factors, and appropriate antibiotic choice to treat clostridium difficile infection. Patient with mild to moderate clostridium difficile infection can be given metronidazole. Severe C.Diff infection will require oral vancomycin treatment and potential early surgical opinion. Severe complicated C.Diff infection will require the combination of oral vancomycin and intravenous metronidazole treatment.