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Hereditary Non-Polyposis Colon Cancer (HNPCC) Service Description - Information for doctors and patients.

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22 Nov 2016 - General
 
The Amsterdam II criteria define the minimum requirements for a clinical diagnosis of Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC). There should be at least three relatives with a Lynch/HNPCC-associated cancer (cancer of the colorectum, endometrium, small bowel, ureter or renal pelvis). Other inclusions of this criteria are:
• One should be a first-degree relative to the other two
• At least two successive generations should be affected
• At least one should be di...
 (Total 92 words)
Lynch Syndrome or HNPCC (Hereditary Non-Polyposis Colon Cancer) is an autosomal dominant inherited disease in which colorectal cancer is due to the inactivation of 1 of the protein involved in DNA proofreading (usually the MLH1 and MSH2). This will lead to early onset of colon cancer and extra colonic cancer like the gastric, gallbladder, biliary tract, renal cell, urinary tract, ovarian, and endometrial malignancy. Colon cancer arises from discrete adenomas, which rapidly accumulate point mutat...
 (Total 102 words)