Common drugs with uncommonly known fatal drug - drug interatctionCreated by:
I will like to create a post with everyone to share some common drug drug interaction that we encounter in our work. Sometimes, patients come with so many medications, I just got so worried that an additional prescription will cause some severe drug drug interaction. I find this MIMS site extremely helpful. When I encounter any patient with polypharmacy, I will make sure I search mims on any medication I want to prescribe and focus on potential fatal drug -drug interatction. If the patient suffers any advserse side effect from a drug, it may be defensible. However, if we prescribe a medication with a known fatal drug drug interatction with another medication the patient is already on, we will be very much liable to a negligent lawsuit. Has anyone got any commonly prescribed drugs causing not so uncommon fatal drug - drug interatction?
Acne: Tetracycline class antibiotics + Isotretinoin -> Pseudotumor cerebri
Hyperlipidemia + infection: Clarithromycin + simvastatin -> Rhabdomyolysis
Contraception + Infection: Antibiotics + Oral contraception -> Reduced OCP absorption ( I find this fatal because if a couple is is terminate an unwanted pregnancy, we have a fatality )
IHD with ED : Viagra + nitrates -> Severe hypotension due to 2 vasodilators
Please add to the list : )