Journal Article Discussion :Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trialCreated by:
Ulcerative colitis is a sub-type of Inflammatory Bowel Disease (IBD), that occur due to inflammation and ulceration of colonic mucosa. Ulcerative colitis will only affect the large bowel / colon. The aetiology of this condition is unknown, but a few factors were speculated that might cause ulcerative colitis. This is a chronic disease. Intravenous steroid is the standard therapy used to manage the acute flare of ulcerative colitis, and usually it is effective to induce remission of disease. But, sometime, acute severe ulcerative colitis may be not responding to steroid therapy, and it require rescue Infliximab treatment (biologic anti-TNF, which is a standard treatment after failure of steroid). Ciclosporin is another option in this scenario. The study above, which was published in The Lancet (Gastroenterology & Hepatology), has showed that there is no different between infliximab and ciclosporin in patients with steroid-resistant acute ulcerative colitis. Would you consider to use ciclosporin in steroid resistant acute severe ulcerative colitis ???? Or we should just use Infliximab ??